:root{--ars-dblue:hsl(208,75%,30%);--ars-dblue2:hsl(208,75%,25%);--ars-dblue3:hsl(208,75%,20%);--ars-mblue:hsl(208,55%,45%);--ars-mblue2:hsl(208,55%,40%);--ars-mblue3:hsl(208,55%,35%);--ars-lblue:hsl(210,63%,93%);--ars-lblue2:hsl(210,63%,90%);--ars-yellow:hsl(46,100%,90%);--ars-yellow2:hsl(45,100%,81%);--ars-yellow3:hsl(45,100%,51%);--bs-danger-bg-subtle:#f8d7da;--bs-danger-border-subtle:#f1aeb5;--bs-danger-text-emphasis:#58151c;--bs-success-focus-shadow:0 0 0 .25rem rgba(60,153,110,.5);--bs-danger-focus-shadow:0 0 0 .25rem rgba(225,83,97,.5)}html,body{height:100%;width:100%;position:static;overflow-y:auto;background-color:white}legend{font-size:1em}h1{font-size:1em;margin:0;padding:0}h2{font-size:1.4em}h3{font-size:1.3em}h4{font-size:1.2em}h5{font-size:1em}ul{padding-left:2.2em}input{background-color:white}input[type=checkbox]:hover,input[type=radio]:hover{cursor:pointer}a{text-decoration:none}a:hover{text-decoration:underline}a.btn:hover{text-decoration:none}.btn.btn-primary{background-color:var(--ars-mblue);color:white}.btn.btn-outline-primary{background-color:white;color:var(--ars-mblue2)}.btn.btn-primary,.btn.btn-outline-primary{border-color:var(--ars-mblue)}.btn.btn-primary:hover,.btn.btn-primary:focus,.btn.btn-outline-primary:hover,.btn.btn-outline-primary:focus{background-color:var(--ars-mblue2);border-color:var(--ars-mblue2);color:white}.btn.btn-primary:active,.btn.btn-outline-primary:active{background-color:var(--ars-mblue3);border-color:var(--ars-mblue3);color:white}.btn.btn-primary:focus-visible,.btn.btn-outline-primary:focus-visible{box-shadow:0 0 0 .25rem hsla(208,55%,45%,.5)}.btn:disabled{background-color:#ffffff95;border:1px solid #667;color:#667;opacity:unset}.btn-check:checked+.btn.btn-outline-primary{background-color:var(--ars-mblue)}.btn-check:checked+.btn.btn-primary{background-color:var(--ars-mblue2)}.btn.btn-darkblue{background-color:var(--ars-dblue);border-color:var(--ars-dblue);color:white}.btn.btn-darkblue:hover,.btn.btn-darkblue:focus{background-color:var(--ars-dblue2);border-color:var(--ars-dblue2);color:white}.btn.btn-darkblue:focus-visible{box-shadow:0 0 0 .25rem hsla(208,75%,45%,.5)}.btn.btn-darkblue:active{background-color:var(--ars-dblue3);border-color:var(--ars-dblue3);color:white}.btn-jumbo{padding:2rem;display:flex;flex-direction:column;text-align:center;align-items:center;justify-content:center;font-size:1.7rem;text-transform:uppercase}.btn-jumbo div:first-child:not(:last-child){font-size:.7em}#skiplink a,#skiplink a:hover{position:absolute;left:0;top:-500px;width:1px;height:1px;overflow:hidden}#skiplink a:active,#skiplink a:focus{position:static;display:block;width:auto;height:auto}#site-header-wrapper{width:100%;background-color:white;padding:0;margin:0}#site-header a{padding:23px 23px 23px 23px;width:100%;max-width:500px;display:inline-block;line-height:0}#site-header img{max-height:54px}#site-header .usa-banner{padding:.7rem 23px;background-color:#f0f0f0;color:#1b1b1b}#site-header .usa-banner__header-text{margin:0;font-size:.8rem;line-height:1.1;font-family:Open Sans,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica,Arial,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol}#site-header img.usa-banner__header-flag{vertical-align:baseline;margin-right:.3rem;width:1rem}section#homepage-alert-banner{padding:.7rem 23px;background-color:#fbfbc2;color:#1b1b1b}.homepage-alert-banner__header-text{margin:0;font-size:.8rem;line-height:1.1;font-family:Open 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bottom,rgba(255,255,255,255),rgba(255,255,255,0));display:none}#scroll-content{position:relative;min-height:100%;padding-bottom:180px;margin:0}#footer{bottom:0;position:absolute;height:180px;width:100%;text-align:center;background-color:#e4e4e4;border-top:1px solid #a0a0a0;padding:10px;color:#000;margin-top:0;display:none}#site-footer-links{margin-bottom:10px}#nih-footer-links{margin-bottom:10px}#footer a{color:#2c5d88;white-space:nowrap;margin:0 .5em}#footer a:visited{color:#2c5d88}.navmenu-link{font-weight:bold;display:block;color:var(--ars-dblue);background-color:white;margin-bottom:20px;margin-right:20px;margin-left:20px;padding:4px 8px 4px 8px;border:solid var(--ars-dblue) 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.mobile-menu-item:hover{background-color:var(--ars-dblue);text-decoration:none;color:white}.mobile-menu-item:focus{background-color:var(--ars-dblue);text-decoration:none;color:white;outline:0}.mobile-menu-icon{margin-right:10px}#pages{padding:20px;background-color:white}.page-title{margin-top:0;margin-bottom:20px;background-color:var(--ars-dblue);padding:10px 20px;color:white;font-weight:bold;line-height:1em}.page-title i{padding-right:10px}.sub-header{color:black;background-color:var(--ars-lblue);padding:10px 20px;border:solid var(--ars-dblue) 1px;margin:0}.sub-header-content{margin:0;padding:0}.sub-header-content p{margin:20px}.sub-header-content li p{margin:10px 0 10px 0}.block-header{margin-bottom:0;padding:1rem 1.5rem;font-weight:bold;font-style:italic;font-size:1.2em;background-color:#ccc}#page-my-trial h3{margin-top:1.5rem}.block{background-color:#eee;margin-bottom:20px;padding:1rem 1.5rem}.block>*>a{color:#2c5d88}.tool-section-desc{background-color:white;padding:1rem;margin:1.5rem 0}.tool-section-desc h5{font-size:1.25rem;font-weight:bold;margin-bottom:1.25rem}.tool-section-desc .list-group-flush li{padding:1.25rem .5rem}#page-home h3{margin-bottom:1rem;font-size:1.75em;text-align:center}.block-bg-blue{padding:1rem 1.25rem;background-color:var(--ars-lblue)}#home-cols .btn-jumbo{width:min(100%,21rem);height:100%;margin-left:auto;margin-right:auto}#home-cols{display:grid;grid-template-columns:1fr 1fr;column-gap:2rem;font-size:1.25em}@media(min-width:768px) and (max-width:calc(340px - -40px - -4rem - -44rem)),(max-width:calc(40px - -4rem - -44rem)){#home-cols{grid-template-columns:1fr;font-size:unset}#page-home .block-bg-blue{padding:.5rem 1rem}#page-home .block-bg-blue:last-of-type{padding-bottom:1rem}#col1-text{order:1}#col1-btn{order:2}#col2-text{order:3}#col2-btn{order:4}}#masterToggles{margin:20px 0}#masterToggles button{margin-right:10px}#aboutAccordion h4{color:var(--ars-dblue)}.accordion-button{font-size:1em;color:var(--ars-dblue);background-color:var(--ars-lblue)}.card-header .accordion-button{background-color:white}.bordered{margin:0 20px;border:solid #b4b4b4 1px}.bordered>ul>li{padding:5px}.table.table-bordered td,.table.table-bordered th{border:solid #b4b4b4 1px}.card{margin:1em 0}.card p:last-child{margin-bottom:0}details p{margin-left:1.5rem}summary{font-weight:bold;font-style:italic}summary:hover{color:var(--ars-dblue2)}details[open] summary{margin-bottom:.75rem}form b,form strong{font-weight:bold}#tool-form{padding:1.5rem;background-color:#eee}#tool-form #reset-btn{display:block;margin-left:auto;margin-right:0}#tool-form #reset-btn i{margin-right:.5rem}#tool-form>section{margin-top:1.5rem}#tool-form>section>p{margin:1rem 1.75rem}.page li:not(.list-group-item){margin-bottom:.5em}#tool-form .card{border-radius:0;margin:0}.card.open{box-shadow:0 0 1.5rem hsla(0,0%,0%,25%);z-index:1}.card.open .card-header>:not(.button-header){display:none}#tool-form .card-header{background-color:var(--ars-lblue);padding:1.5rem 3rem;border:0;border-radius:0!important}.card-header .button-header{display:flex;align-items:center;justify-content:space-between;flex-wrap:wrap}#tool-form .card-body{background-color:white;padding:2rem 3rem}#tool-form .card-body>p{margin-bottom:2rem}#tool-form .card-body>:last-child{margin-bottom:0!important}form>section{background-color:white}form>section .card:not(:last-of-type){border-bottom:0}.card .btn{margin:.25rem}.card-header .button-header{margin-bottom:1rem}.btn-edit i{margin-right:.5rem}.card.open .btn-edit{display:none}.card.open .card-header .button-header{margin-bottom:0}.card:not(.open) .btn-save,.card:not(.open) .btn-cancel{display:none}.card-body .button-footer{margin-top:2rem}.modal h1{color:var(--ars-dblue);font-size:1.2em;margin:0}.modal .alert{margin:1rem 0 0 0}.modal .btn{margin-left:.75rem}.readonly-field{padding:.25rem}.readonly-label{font-weight:bold;margin-right:.25rem}.modified{background-color:var(--ars-yellow2);font-style:italic}.modified .readonly-label{font-style:normal}#armListHead,#strataDetailsHead{margin:1rem 1.5rem 0 1.5rem}#armListHead{overflow-wrap:anywhere}#armListHead .list-group-item{flex:1;max-width:fit-content;text-align:center;display:grid;grid-template-columns:1fr}#armListHead .list-group-item:first-child{flex:0 0 5rem;text-align:right;background-color:#ddd;font-weight:bold}#armListHead .list-group-item>:first-child{margin-bottom:.5rem}#armListHead .list-group-item>:last-child{align-self:end}#stratavarListHead{border:1px solid rgba(0,0,0,.125);margin-bottom:1rem;border-collapse:separate;border-spacing:0;border-radius:6px}#stratavarListHead{background-color:#ddd}#stratavarListHead tr:not(:last-child),#stratavarListHead tr:not(:last-child) td{border-bottom:1px solid rgba(0,0,0,.125)}#stratavarListHead td{padding:.5rem 1rem}#stratavarListHead .var-name{padding-right:0}#stratavarListHead .var-cats{padding:0;margin-left:-0.25rem;margin-bottom:0}#strataCard .badge{margin:.25rem;font-size:.9em;color:white}.var-name,.arm-name{font-weight:bold;font-style:italic}.strata-summary>p{margin:1.5rem 0}#strataCard .accordion-button{background-color:var(--ars-lblue);color:var(--ars-dblue);font-size:1.2rem}#strataCard .card-header .accordion-button{background-color:hsla(210,63%,93%,50%)}#strataCombos{margin-top:1rem}#comboList ol{margin-bottom:0;padding-left:3rem;font-family:monospace}#comboList li{padding-left:.5rem}#comboList li::marker{color:#6c757d}legend,label{font-weight:bold;margin-right:.25rem}.form-check-label{margin-bottom:.5rem}#tool-form input,#tool-form select{max-width:21em}.strata-cat-fields{display:grid;grid-template-columns:repeat(auto-fill,10em);column-gap:1rem}select.readonly{background-color:#e9ecef}small p{margin:.5em 0}fieldset .list-group:not(.list-group-compact){margin-bottom:2rem}fieldset .list-group-item .radio{margin-right:1rem}fieldset .list-group:not(.list-group-compact) label{margin-top:1rem;font-size:1.2em;color:var(--ars-dblue)}fieldset .list-group-compact .radio-text{padding:.5em 0}fieldset .list-group-compact label{font-weight:normal;display:block}
fieldset .list-group-item-action{border-width:1px!important;margin-top:-1px;margin-bottom:0;background-color:#ffffff95;display:flex;align-items:center}.list-group-item-action:hover{border-color:#0d6efd;color:black}.list-group-item-action:hover input[type="radio"]{border-color:var(--ars-dblue3)}.list-group-item-action:active{background-color:var(--ars-lblue2)}fieldset .form-check-label.stretched-link{cursor:pointer}.list-group-item.active{background-color:var(--ars-lblue);color:black}.list-group-item.disabled{background-color:#eee;color:#667}.list-group-item.disabled label{color:inherit!important}.card .btn-group .btn{margin-left:0;margin-right:0}label.btn.btn-outline-primary{background-color:#e0ecf895;font-size:1.25em;font-weight:bold;padding:.5em 1em}fieldset+small.form-text{display:block;margin-top:-1.5rem}.form-switch{padding:.5rem;margin-bottom:2rem;width:fit-content;border-radius:6px;background-color:var(--ars-lblue)}.form-switch .form-check-input{font-size:1.2em;margin-left:0;margin-right:1rem}.form-switch .form-check-input:checked{background-color:var(--ars-mblue)}.form-switch label{cursor:pointer;margin-bottom:0}.form-switch label:hover,.form-switch input:hover+label,.form-switch input:focus+label{color:var(--ars-dblue)}.field-box{margin:1.5rem 0;padding:.1rem 1rem}.field-box-label{color:var(--ars-dblue);font-size:1.2rem;padding:1rem 0;margin:0}.field-box,fieldset .list-group{background-color:var(--ars-lblue)}.field:not(:last-child),fieldset:not(:last-child){margin-bottom:2rem}.strata-cat-fields label,.strata-cat-fields .form-text,.strata-cat-fields .errorlist{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);border:0}.block-bg-gray{padding:1rem;margin-left:auto;margin-right:auto;width:fit-content;background-color:#eee}#input-disclaimer-text{font-size:.875em;max-width:45rem}#id_disclaimer-group{margin-bottom:-0.5rem!important}#id_disclaimer-group label{width:100%}#id_disclaimer-group .is-invalid ~ .form-check-label{color:var(--bs-danger-text-emphasis)}#id_disclaimer-errors{margin-top:-0.5rem}.alert-danger:focus-visible{outline:0;box-shadow:var(--bs-danger-focus-shadow)}.alert-success:focus-visible{outline:0;box-shadow:var(--bs-success-focus-shadow)}.alert{margin-bottom:20px;border-radius:0}.card-header .alert{margin:1rem 0}.card-body .alert{margin-top:2rem}.errorlist{list-style-type:none;padding:0;margin-bottom:0}fieldset+.errorlist{margin-top:-1.5rem}.form-group fieldset+.errorlist{margin-top:-2.75rem;margin-bottom:1.5rem}.errorlist li{border:1px solid var(--bs-danger-border-subtle);background-color:var(--bs-danger-bg-subtle);color:var(--bs-danger-text-emphasis);margin:.5rem 0;padding:.25rem;width:fit-content;border-radius:6px}fieldset ~ .invalid-feedback,.g-recaptcha ~ .invalid-feedback{display:block}#data-load-spinner{display:none;margin-top:5px;text-align:center}.form-confirm-section,.form-debug{text-align:center;padding:1rem;margin-top:1rem}#launcher-main .form-confirm-section .form-alert{margin:0 10% 1% 10%}#launcher-main .form-confirm-section .form-btn.btn{display:inline-block;vertical-align:top;margin:.25rem}.form-debug .btn{width:140px}#launcher-main .form-confirm-section .btn-outline-secondary{color:#667;background-color:white;border-color:#787878}#launcher-main .form-confirm-section .btn-outline-secondary:hover,#launcher-main .form-confirm-section .btn-outline-secondary.active{color:white;background-color:#787878;cursor:pointer}#launcher-main #queue-btn{min-width:min(400px,90%);padding:.5rem}.infohover{cursor:help;margin-right:.25rem}.ars-citation{margin-left:3em;font-style:normal}.learn-section{margin-bottom:12px}.spam-detection{visibility:hidden;width:1px;height:1px;opacity:0;position:absolute}#reference-list ol{margin:20px 40px 10px 100px}#reference-list ol li{padding:5px}#page-load-spinner{display:none;margin-top:20px;text-align:center;font-size:2em}.strong{font-weight:bold}@media(min-width:768px) and (max-width:940px),(max-width:600px){#tool-form{padding:10px}#tool-form>section:first-of-type{margin-top:10px}#tool-form h3,.tool-input-block-header,.tool-input-block{padding:1rem}#tool-form>section>p{margin:1rem}#tool-form .card-header,#tool-form .card-body{padding:1.5rem 1rem}#tool-form .card-body>p{margin-bottom:1.5rem}#stratavarListHead td{display:block;width:100%}#stratavarListHead tr td:first-child{padding-top:.5rem;padding-bottom:0;border-bottom:0}#stratavarListHead tr td:last-child{padding-top:0;padding-bottom:.75rem}#armListHead{display:inline-block}#armListHead .list-group-item:first-child{border-bottom-left-radius:0;border-top-right-radius:inherit}#armListHead .list-group-item:last-child{border-top-right-radius:0;border-bottom-left-radius:inherit}#armListHead .list-group-item+.list-group-item{border-left-width:1px;border-top:0}#armListHead .list-group-item{grid-template-columns:1fr 5rem;max-width:100%}#armListHead .list-group-item>:first-child{text-align:left;margin-bottom:0;min-width:6rem}#armListHead .list-group-item>:last-child{text-align:center;align-self:center}fieldset .list-group-item{display:block}fieldset .list-group-item .radio{float:left;margin-top:.75rem}fieldset .list-group-item:not(.compact) label{margin-top:.5rem}}@media(min-width:768px) and (max-width:calc(2*20px - -2*10px - -2*1rem - -304px - -340px)),(max-width:calc(2*20px - -2*10px - -2*1rem - -304px)){.g-recaptcha{transform:scale(0.8);transform-origin:0 0}}@media(max-width:calc(60rem - -340px)){#launcher-main{width:100%}}@media(min-width:768px){#mobile-menu,#mobile-menu-toggle{display:none}#right-column{margin-left:340px;overflow-y:scroll}#left-column{display:block}#scroll-gradient-overlay{display:block;left:320px}.page-old{padding-left:20px;padding-right:20px}html,body{overflow-y:hidden}#scroll-content{padding-bottom:140px}#footer{margin-top:0;position:absolute;height:140px}}@media(min-width:900px){#scroll-content{padding-bottom:160px}#footer{margin-top:0;position:absolute;height:160px}}@media print{html,body{min-height:auto;height:auto}
body{margin:0}#left-column{display:None}#right-column{width:100%!important;left:0!important}#right-column-content{border-left:0;overflow-x:visible;overflow-y:visible}#footer{display:None}#pages{padding:0}}